Article

Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant, UBB <sup>+1</sup>

2025-01-02

Abstract excerpt

UBB⁺¹, a ubiquitin variant protein resulting from a frameshift in the ubiquitin-B gene, is a pathological hallmark of Alzheimer disease (AD). At the cellular level, UBB⁺¹ disrupts the ubiquitin-proteasome system while inducing autophagy. Notably, UBB⁺¹ itself is secreted via autophagosome-like vesicles. Here, we demonstrate that UBB⁺¹ can be removed from the cell by degradative and secretory autophagy. SQSTM1/p62...

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Literature Corpus work: 8cca9779-6ccd-54c6-9ac0-5a7601e3ee6b
DOI: 10.1101/2024.12.31.630908

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