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Article

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Human molecular genetics - 1 May 2002

Ravikumar Brinda, Duden Rainer, Rubinsztein David C

Abstract excerpt

Protein conformational disorders (PCDs), such as Alzheimer's disease, Huntington's disease (HD), Parkinson's disease and oculopharyngeal muscular dystrophy, are associated with proteins that misfold and aggregate. Here we have used exon 1 of the HD gene with expanded polyglutamine [poly(Q)] repeats and enhanced green fluorescent protein tagged to 19 alanines as models for aggregate-prone proteins, to investigate...

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PMID: 11978769
DOI: 10.1093/hmg/11.9.1107

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