Article

Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data

2022-04-15

Abstract excerpt

Precise mechanism-based gene expression signatures (GESs) have been developed in appropriate in vitro and in vivo model systems, to identify important cancer-related signalling processes. However, some GESs originally developed to represent specific disease processes, primarily with an epithelial cell focus, are being applied to heterogeneous tumour samples where the expression of the genes in the signature may...

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Literature Corpus work: 5c642ffa-b17b-5bf6-bdd5-d3058b85d965
DOI: 10.1101/2022.04.15.488354

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