Article

Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancer

2026-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Epithelial heterogeneity defines high-grade serous ovarian carcinoma (HGSC), yet principles that generate this diversity within and across tumours remain unclear. Integrating single-cell RNA sequencing (scRNA-seq) data from 13 studies (1,980,703 cells, 371 samples), we resolve a dominant axis of secretory cell polarization spanning proliferative, progenitor-like SecA cells and quiescent SecB cel...

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Literature Corpus work: 99dbdb8a-293b-5325-9f8f-b92651c33266
DOI: 10.64898/2026.05.27.727977

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