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Article

Decoupling epithelial-mesenchymal transitions from stromal profiles by integrative expression analysis

10 May 2021

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) is the most commonly cited mechanism for cancer metastasis, but it is difficult to distinguish from profiles of normal stromal cells in the tumour microenvironment. In this study we use published single cell RNA-seq data to directly compare mesenchymal signatures from cancer and stromal cells. Informed by these comparisons, we developed a computational framework to...

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PMID: 33972543
DOI: 10.1038/s41467-021-22800-1

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