Article

Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance

2022-02-18

Abstract excerpt

<h4>ABSTRACT</h4> BRAF V600E is prototypical of oncogenic mutations that can be targeted therapeutically and treatment of BRAF-mutant melanomas with RAF and MEK inhibitors results in rapid tumor regression. However, drug-induced rewiring causes BRAF V600E melanoma cells to rapidly acquire a drug-adapted state. In patients this is thought to promote acquisition or selection for resistance mutations and disease r...

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Literature Corpus work: 5c5be5bb-c924-543b-9b67-2fa6572b632f
DOI: 10.1101/2022.02.17.480899

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