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Article

Function and evolution of B-Raf loop dynamics relevant to cancer recurrence under drug inhibition.

Journal of biomolecular structure & dynamics - 1 Jan 2022

Babbitt Gregory A, Lynch Miranda L, McCoy Matthew, Fokoue Ernest P, Hudson André O

Abstract excerpt

Oncogenic mutations in the kinase domain of the B-Raf protein have long been associated with cancers involving the MAPK pathway. One constitutive MAPK activating mutation in B-Raf, the V600E (valine to glutamate) replacement occurring adjacent to a site of threonine phosphorylation (T599) occurs in many types of cancer, and in a large percentage of certain cancers, such as melanoma. Because ATP binding activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32897175
DOI: 10.1080/07391102.2020.1815578

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