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Article

Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance.

Molecular systems biology - 10 Feb 2023

Fröhlich Fabian, Gerosa Luca, Muhlich Jeremy, Sorger Peter K

Abstract excerpt

BRAF is prototypical of oncogenes that can be targeted therapeutically and the treatment of BRAFV600E melanomas with RAF and MEK inhibitors results in rapid tumor regression. However, drug-induced rewiring generates a drug adapted state thought to be involved in acquired resistance and disease recurrence. In this article, we study mechanisms of adaptive rewiring in BRAFV600E melanoma cells using an energy-based...

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Share to Drug Resistance, Neoplasm
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitogen-Activated Protein Kinase Kinases

Share to Neoplasm Recurrence, Local

Share to Protein Kinase Inhibitors

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Share to Proto-Oncogene Proteins B-raf

Source

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Identifiers

PMID: 36700386
DOI: 10.15252/msb.202210988
PMCID: PMC9912026

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