Article

Spatio-Genetic and Phenotypic Modelling Elucidates Resistance and Re-Sensitisation to Treatment in Heterogeneous Melanoma

2018-11-07

Abstract excerpt

Although novel targeted therapies have significantly improved the overall survival of patients with advanced melanoma, understanding and combatting drug resistance remains a major clinical challenge. Using partial differential equations, we describe the evolution of a cellular population through time, space, and phenotype dimensions, in the presence of various drug species. We then use this framework to explore mo...

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Literature Corpus work: 11b33f00-507f-5f6b-9d2f-7f1ddd2bafa7
DOI: 10.1101/463877

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