Article
Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Cell systems - 18 Nov 2020
Gerosa Luca, Chidley Christopher, Fröhlich Fabian, Sanchez Gabriela, Lim Sang Kyun, Muhlich Jeremy, Chen Jia-Yun, Vallabhaneni Sreeram, Baker Gregory J, Schapiro Denis, Atanasova Mariya I, Chylek Lily A, Shi Tujin, Yi Lian, Nicora Carrie D, Claas Allison, Ng Thomas S C, Kohler Rainer H, Lauffenburger Douglas A, Weissleder Ralph, Miller Miles A, Qian Wei-Jun, Wiley H Steven, Sorger Peter K
Abstract excerpt
Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth of tumors but often leads to the emergence of slowly dividing persister cells, which constitute a reservoir for the selection of drug-resistant clones. In BRAFV600E melanomas, RAF and MEK inhibitors efficiently block oncogenic signaling, but persister cells emerge. Here, we show that persister cells escape drug-induced...
Topics
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- Extracellular Signal-Regulated MAP Kinases
- Gene Expression Regulation, Neoplastic
- Humans
- MAP Kinase Signaling System
- Melanoma