Article

Mechanistic insights from replica exchange molecular dynamics simulations into mutation induced disordered-to-ordered transition in Hahellin, a βγ-crystallin

2018-11-20

Abstract excerpt

Intrinsically disordered proteins (IDPs) form a special category because they lack a unique well-folded 3D structure under physiological conditions. They play crucial role in cell signaling, regulatory functions and responsible for several diseases. Although, they are abundant in nature, only a small fraction of it has been characterized till date. Such proteins adopt a range of conformations and can undergo trans...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00c0b358-5168-5878-8a92-ca01ffe13872
DOI: 10.1101/475277

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanistic insights from replica exchange molecular dynamics simulations into mutation induced disordered-to-ordered transition in Hahellin, a βγ-crystallinDOI 10.1101/475277Read

Replica exchange molecular dynamics simulations reveal self-association sites in M-crystallin caused by mutations provide insights of cataract.Semantic proximity Read

Evolutionary remodeling of βγ-crystallins for domain stability at cost of Ca2+ binding.Semantic proximity Read

Double Domain Swapping in Human <i>γ</i> C and <i>γ</i> D Crystallin Drives Early Stages of AggregationSemantic proximity Read

Do intrinsically disordered proteins possess high specificity in protein-protein interactions?Semantic proximity Read

Differential local stability governs the metamorphic fold-switch of bacterial virulence factor RfaHSemantic proximity Read

Effect of mutations on the folding and stability of γD-crystallin protein.Semantic proximity Read

Small molecule binding to disordered proteinsSemantic proximity Read

Decoding the molecular design principles underlying Ca(2+) binding to βγ-crystallin motifs.Semantic proximity Read

Influence of Cataract Causing Mutations on αA-Crystallin: A Computational Approach.Semantic proximity Read

Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditionsSemantic proximity Read

Biophysical and biochemical aspects of antifreeze proteins: Using computational tools to extract atomistic information.Semantic proximity Read

Analysis of secondary structural and physicochemical changes in protein-protein complexes.Semantic proximity Read