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Article

Divergent evolution of protein conformational dynamics in dihydrofolate reductase.

Nature structural & molecular biology - 1 Nov 2013

Bhabha Gira, Ekiert Damian C, Jennewein Madeleine, Zmasek Christian M, Tuttle Lisa M, Kroon Gerard, Dyson H Jane, Godzik Adam, Wilson Ian A, Wright Peter E

Abstract excerpt

Molecular evolution is driven by mutations, which may affect the fitness of an organism and are then subject to natural selection or genetic drift. Analysis of primary protein sequences and tertiary structures has yielded valuable insights into the evolution of protein function, but little is known about the evolution of functional mechanisms, protein dynamics and conformational plasticity essential for activity....

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Source

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Identifiers

PMID: 24077226
DOI: 10.1038/nsmb.2676
PMCID: PMC3823643

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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