Article

Interaction of HS1BP3 with cortactin modulates TKS5 localisation and cancer malignancy

2025-07-15

Abstract excerpt

We have previously shown that HS1BP3 interacts with the SH3 domain of cortactin, a protein that contributes to a malignant phenotype in cancers. Here we demonstrate that high expression of HS1BP3 is predictive of poorer outcomes for gastric adenocarcinoma and triple negative breast carcinoma patients. We mapped the HS1BP3-SH3 interaction site to the third proline rich region (PRR3.1) of HS1BP3 and show that cells...

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Identifiers and source

Literature Corpus work: 5c4511fc-2205-571f-84df-563cfd18f526
DOI: 10.1101/2025.07.14.664640

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