Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.

PloS one - 1 Jan 2014

Cejudo-Martin Pilar, Yuen Angela, Vlahovich Nicole, Lock Peter, Courtneidge Sara A, Díaz Begoña

Abstract excerpt

Tks5 is a scaffold protein and Src substrate involved in cell migration and matrix degradation through its essential role in invadosome formation and function. We have previously described that Tks5 is fundamental for zebrafish neural crest cell migration in vivo. In the present study, we sought...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Cleft Palate
Share to Gene Order

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphate-Binding Proteins

Share to Phosphoproteins

Share to Proteasome Endopeptidase Complex

Share to Proteolysis

Share to src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25259869
DOI: 10.1371/journal.pone.0107674
PMCID: PMC4178035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25259869-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.PMID 25259869Read ↗

Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome.Semantic proximity Read ↗

The Sh3Pxd2bnee-/- mouse reveals developmental features of Frank-ter Haar syndrome.Semantic proximity Read ↗

Significance of the Tks4 scaffold protein in bone tissue homeostasisSemantic proximity Read ↗

Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.Semantic proximity Read ↗

The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineagesSemantic proximity Read ↗

The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.Semantic proximity Read ↗

High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6.Semantic proximity Read ↗

Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23.Semantic proximity Read ↗

The novel zebrafish model pretzel demonstrates a central role for SH3PXD2B in defective collagen remodelling and fibrosis in Frank-Ter Haar syndrome.Semantic proximity Read ↗

Differential Expression of TKS4 Isoforms and Their Role in Cellular Processes in Breast CancerSemantic proximity Read ↗

DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformationsSemantic proximity Read ↗

A viable mouse model for Netherton syndrome based on mosaic inactivation of the Spink5 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.