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Article

Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.

PloS one - 1 Jan 2014

Cejudo-Martin Pilar, Yuen Angela, Vlahovich Nicole, Lock Peter, Courtneidge Sara A, Díaz Begoña

Abstract excerpt

Tks5 is a scaffold protein and Src substrate involved in cell migration and matrix degradation through its essential role in invadosome formation and function. We have previously described that Tks5 is fundamental for zebrafish neural crest cell migration in vivo. In the present study, we sought to investigate the function of Tks5 in mammalian development by analyzing mice mutant for sh3pxd2a, the gene encoding...

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PMID: 25259869
DOI: 10.1371/journal.pone.0107674
PMCID: PMC4178035

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