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Article

Tks5 SH3 domains exhibit differential effects on invadopodia development.

PloS one - 1 Jan 2020

Daly Christina, Logan Brewer, Breeyear Joseph, Whitaker Kelley, Ahmed Maryam, Seals Darren F

Abstract excerpt

The Src substrate Tks5 helps scaffold matrix-remodeling invadopodia in invasive cancer cells. Focus was directed here on how the five SH3 domains of Tks5 impact that activity. Mutations designed to inhibit protein-protein interactions were created in the individual SH3 domains of Tks5, and the constructs were introduced into the LNCaP prostate carcinoma cell line, a model system with intrinsically low Tks5...

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Identifiers

PMID: 31999741
DOI: 10.1371/journal.pone.0227855
PMCID: PMC6991978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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