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Article

FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2014

Cen Gang, Ding Hong-Hua, Liu Bin, Wu Wei-Dong

Abstract excerpt

Cortactin, an actin-interacting protein, is implicated in cytoskeletal architecture and often amplified in several types of cancer including gastric adenocarcinomas. Downregulation of cortactin decreases cell migration and invasion. However, how to regulate cortactin in gastric cancer remains largely unknown. Here, we report that FBXL5 interacts with and targets cortactin for ubiquitylation and subsequent...

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PMID: 24867096
DOI: 10.1007/s13277-014-2104-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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