Article
The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.
Cancer research - 15 Jul 2013
Ahn Ryuhjin, Sabourin Valerie, Ha Jacqueline R, Cory Sean, Maric Gordana, Im Young Kyuen, Hardy W Rod, Zhao Hong, Park Morag, Hallett Michael, Siegel Peter M, Pawson Tony, Ursini-Siegel Josie
Abstract excerpt
ShcA (SHC1) is an adapter protein that possesses an SH2 and a PTB phosphotyrosine-binding motif. ShcA generally uses its PTB domain to engage activated receptor tyrosine kinases (RTK), but there has not been a definitive determination of the role of this domain in tumorigenesis. To address this question, we employed a ShcA mutant (R175Q) that no longer binds phosphotyrosine residues via its PTB domain. Here, we...
Topics
- Animals
- Breast Neoplasms
- Cell Line, Tumor
- Disease Progression
- Female
- Fibronectins
- Humans
- Integrin alpha5beta1
- Mammary Neoplasms, Experimental
- Mice