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Article

The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.

The international journal of biochemistry & cell biology - 1 Nov 2011

Martini Melanie, Gnann Alexandra, Scheikl Daniela, Holzmann Bernhard, Janssen Klaus-Peter

Abstract excerpt

SASH1, a member of the SLY-family of signal adapter proteins, is a candidate tumor suppressor in breast and colon cancer. Reduced expression of SASH1 is correlated with aggressive tumor growth, metastasis formation, and inferior prognosis. However, the biological role of SASH1 remains largely unknown. To unravel the function of SASH1, we have analyzed the intracellular localization of endogenous SASH1, and have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21820526
DOI: 10.1016/j.biocel.2011.07.012

Genes

SASH1

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The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.PMID 21820526Read ↗

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