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Article

Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain

14 Feb 2005

Abstract excerpt

BACKGROUND: In human carcinomas, overexpression of cortactin correlates with poor prognosis. Cortactin is an F-actin-binding protein involved in cytoskeletal rearrangements and cell migration by promoting actin-related protein (Arp)2/3 mediated actin polymerization. It shares a high amino acid sequence and structural similarity to hematopoietic lineage cell-specific protein 1 (HS1) although their functions differ...

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PMID: 15710041
DOI: 10.1186/1471-2164-6-15

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