Article

Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

2022-01-04

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor (CAR) costimulatory domains steer the phenotypic output of therapeutic T cells. In most cases these domains are derived from native immune receptors, composed of signaling motif combinations selected by evolution. To explore if non-natural combinations of signaling motifs could drive novel cell fates of interest, we constructed a library of CARs containing ∼2,300 synthe...

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Literature Corpus work: e750aa95-8ce8-56ac-8c03-b12123ba8f59
DOI: 10.1101/2022.01.04.474985

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