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The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

2020-11-09

Abstract excerpt

<h4>ABSTRACT</h4> The high transmissibility of SARS-CoV-2 is related to abundant replication in the upper airways, which is not observed for the other highly pathogenic coronaviruses SARS-CoV-1 and MERS-CoV. We here reveal features of the coronavirus spike (S) protein, which optimize the virus towards different parts of the respiratory tract. First, the SARS-CoV-2 spike (SARS-2-S) reached higher levels in pseudop...

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Literature Corpus work
5c2d0792-59db-5911-b8f3-5194ea572a4c
DOI
10.1101/2020.11.09.374603
Open publication

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The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airwaysDOI 10.1101/2020.11.09.374603
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