Article

Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategies

2021-07-27

Abstract excerpt

<title>Abstract</title> <p>The spike (S) protein of SARS coronavirus 2 (SARS-CoV-2) is an ideal target for the development of specific vaccines or drugs. However, treatments targeting viruses with mutant S proteins that have recently emerged in many countries are limited. Cleavage of the S protein by host proteases is essential for viral infection. Here, we discovered two novel sites (CS-1 and CS-2) in the S prot...

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Literature Corpus work: a6832453-ef71-5e64-a766-ec899098f04c
DOI: 10.21203/rs.3.rs-734963/v1

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