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Article

The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation.

Structure (London, England : 1993) - 3 Jul 2012

He Xiaoping, Byrd Alicia K, Yun Mi-Kyung, Pemble Charles W, Harrison David, Yeruva Laxmi, Dahl Christopher, Kreuzer Kenneth N, Raney Kevin D, White Stephen W

Abstract excerpt

Helicases move on DNA via an ATP binding and hydrolysis mechanism coordinated by well-characterized helicase motifs. However, the translocation along single-stranded DNA (ssDNA) and the strand separation of double-stranded (dsDNA) may be loosely or tightly coupled. Dda is a phage T4 SF1B helicase with sequence homology to the Pif1 family of helicases that tightly couples translocation to strand separation. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22658750
DOI: 10.1016/j.str.2012.04.013
PMCID: PMC3392491

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