Article

TMPRSS2 Transcriptional Inhibition as a Therapeutic Strategy for COVID-19 <strong> </strong>

2020-04-28

Abstract excerpt

There is an urgent need to identify effective therapies for COVID-19. The SARS-CoV-2 host factor protease TMPRSS2 is required for viral entry and thus an attractive target for therapeutic intervention. In mouse, knockout of tmprss2 led to protection against SARS-CoV-1 with no deleterious phenotypes, and in human populations genetic loss of TMPRSS2 does not appear to be selected against. Here, we mined publicly ava...

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Literature Corpus work: 5c150204-e8d8-577c-93ab-80180cab74d9
DOI: 10.20944/preprints202003.0360.v2

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