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Article

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

Cancer discovery - 1 Jun 2020

Stopsack Konrad H, Mucci Lorelei A, Antonarakis Emmanuel S, Nelson Peter S, Kantoff Philip W

Abstract excerpt

TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or...

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Identifiers

PMID: 32276929
DOI: 10.1158/2159-8290.CD-20-0451
PMCID: PMC7437472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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