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Article

Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy.

Genes - 25 Dec 2020

Zarubin Aleksei, Stepanov Vadim, Markov Anton, Kolesnikov Nikita, Marusin Andrey, Khitrinskaya Irina, Swarovskaya Maria, Litvinov Sergey, Ekomasova Natalia, Dzhaubermezov Murat, Maksimova Nadezhda, Sukhomyasova Aitalina, Shtygasheva Olga, Khusnutdinova Elza, Radzhabov Magomed, Kharkov Vladimir

Abstract excerpt

The human serine protease serine 2 TMPRSS2 is involved in the priming of proteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and represents a possible target for COVID-19 therapy. The TMPRSS2 gene may be co-expressed with SARS-CoV-2 cell receptor genes angiotensin-converting enzyme 2 (ACE2) and Basigin (BSG), but only TMPRSS2 demonstrates tissue-specific expression in alveolar cells...

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Identifiers

PMID: 33375616
DOI: 10.3390/genes12010019
PMCID: PMC7823984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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