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Article

TMPRSS2: A Key Host Factor in SARS-CoV-2 Infection and Potential Therapeutic Target

26 Jun 2025

Abstract excerpt

The transmembrane serine protease 2 (TMPRSS2) gene plays a crucial role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by priming the viral spike protein for membrane fusion and facilitating viral entry into host cells.This review aims to explore the molecular function of TMPRSS2, its genetic variations, and its potential as a therapeutic target in corona virus disease 2019 (COVID-19)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40569819
DOI: 10.4274/mmj.galenos.2025.40460

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