Article

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L

2021-01-01

Abstract excerpt

<title>Abstract</title> <p>The entry of SARS-CoV-2 into host cells requires the activation of its spike protein by host cell proteases. The serine protease, transmembrane serine protease 2 (TMPRSS2) and cysteine proteases, cathepsins B, L (CTSB/L) activate spike protein and enabling SARS-CoV-2 entry to the host cell through two completely different and independent pathways. Given that the uncertainty of how SARS-...

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Literature Corpus work: 60588ca5-c6de-58fa-9ea0-2830016ac3ae
DOI: 10.21203/rs.3.rs-138273/v1

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