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Article

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

11 Dec 2020

Abstract excerpt

Significance New therapeutic targets are urgently needed against SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic. Results in this study show that targeting the transcriptional regulation of host entry factors TMPRSS2 and ACE2 is a viable treatment strategy to prevent SARS-CoV-2 infection. In particular, inhibitors of androgen receptor (AR) or bromodomain and extraterminal domain (BET) proteins...

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PMID: 33310900
DOI: 10.1073/pnas.2021450118

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