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Article

Reproducibility in the UK biobank of genome-wide significant signals discovered in earlier genome-wide association studies.

Scientific reports - 20 Sept 2021

O'Sullivan Jack W, Ioannidis John P A

Abstract excerpt

With the establishment of large biobanks, discovery of single nucleotide variants (SNVs, also known as single nucleotide polymorphisms (SNVs)) associated with various phenotypes has accelerated. An open question is whether genome-wide significant SNVs identified in earlier genome-wide association studies (GWAS) are replicated in later GWAS conducted in biobanks. To address this, we examined a publicly available...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34545148
DOI: 10.1038/s41598-021-97896-y
PMCID: PMC8452698

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