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Replication of Known and Identification of Novel Associations in Biobank-Scale Datasets: A Survey Using UK Biobank and FinnGen.

Genes - 17 Jul 2024

Tkachenko Alexander A, Changalidis Anton I, Maksiutenko Evgeniia M, Nasykhova Yulia A, Barbitoff Yury A, Glotov Andrey S

Abstract excerpt

Over the last two decades, numerous genome-wide association studies (GWAS) have been performed to unveil the genetic architecture of human complex traits. Despite multiple efforts aimed at the trans-biobank integration of GWAS results, no systematic analysis of the variant-level properties affecting the replication of known associations (or identifying novel ones) in genome-wide meta-analysis has yet been...

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PMID: 39062709
DOI: 10.3390/genes15070931
PMCID: PMC11275374

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