Article

Perturbation analysis in the N-terminal domain of hPGK1: a biophysical, structural and statistical mechanical study

2022-08-11

Abstract excerpt

Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer development and rare genetic diseases that affect several of its features. To investigate how mutations affect hPGK1 folding landscape and interaction networks, we have introduced mutations at a buried site in the N-terminal domain (F25 mutan...

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Literature Corpus work: b7f0a0b3-9155-52be-9d29-4701db59a07d
DOI: 10.21203/rs.3.rs-1945879/v1

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