Article

Molecular basis for plasma membrane recruitment of PI4KA by EFR3

2024-04-30

Abstract excerpt

The lipid kinase phosphatidylinositol 4 kinase III alpha (PI4KIIIα/PI4KA) is a master regulator of the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a heterotrimeric complex with its regulatory proteins TTC7 and FAM126. Fundamental to PI4KA activity is its targeted recruitment to the plasma membrane by the lipidated proteins EFR3A and EFR3B. Here, we report a cryo-EM structure o...

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Literature Corpus work: 3d7f9346-1ebf-564e-a5b5-ccd851ce8fb8
DOI: 10.1101/2024.04.30.587787

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