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Article

Sirt6 attenuates chondrocyte senescence and osteoarthritis progression

10 Dec 2022

Abstract excerpt

Sirt6 has been implicated as a key regulator in aging-related diseases, including osteoarthritis. However, its functional role and molecular mechanism in chondrocyte senescence and osteoarthritis pathophysiology remain largely undefined. Here we show that Sirt6 deficiency exaggerates chondrocyte senescence and osteoarthritis progression, whereas intra-articular injection of adenovirus-Sirt6 markedly attenuates...

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PMID: 36496445
DOI: 10.1038/s41467-022-35424-w

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