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Article

Macrophage migration inhibitory factor reversed senescent phenotype in human chondrocytes in vitro.

Molecular biology reports - 21 Jan 2024

Fu Zhenlan, Li Qingqing, Jiang Peiyao, Song Xiongbo, Yang Junjun, Chen Guangxing, Gong Xiaoyuan, Yang Liu

Abstract excerpt

BACKGROUND: The senescence of chondrocytes, which is closely linked to the development of osteoarthritis (OA), has been found to be influenced by the inflammatory environment of joint cavity. However, there remains a lack of comprehensive understanding regarding the specific mechanisms through which cytokine impacts chondrocytes senescence. PURPOSE: To investigate the effects of MIF on the chondrocytes senescence...

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PMID: 38245877
DOI: 10.1007/s11033-023-09101-0

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