Article
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.
Nature reviews. Rheumatology - 1 Jan 2021
Coryell Philip R, Diekman Brian O, Loeser Richard F
Abstract excerpt
The development of osteoarthritis (OA) correlates with a rise in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been implicated in cartilage degradation and OA. Age-related mitochondrial dysfunction and associated oxidative stress might induce senescence in joint tissue cells. However, senescence is not the only driver of OA, and the mechanisms by...
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