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Article

Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis

8 Sept 2015

Abstract excerpt

Osteoarthritis (OA) is a chronic degenerative joint disorder commonly associated with metabolic syndrome. As ageing and obesity has a great impact on the initiation/severity of OA, herein we sought to investigate the involvement of Sirt6 in the crosstalk between ageing and metabolic syndrome/OA. Sirt6 haploinsufficiency in mice promoted the expression of inflammatory cytokines in the IPFP. Enhanced inflammation...

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PMID: 26362183
DOI: 10.1016/j.bbrc.2015.09.019

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