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Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

13 Nov 2023

Abstract excerpt

Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on neuropathologies is unknown. Here we show that senescent cells accumulate in aged human brain organoids and that senolytics reduce age-related inflammation and rejuvenate...

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PMID: 37957361
DOI: 10.1038/s43587-023-00519-6

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