Back to search

Article

CD24 and CD27 resolve ontogeny and gradual differentiation of CD11c+ atypical memory B cells after malaria infection

2025-09-17

Abstract excerpt

Atypical B cells (ABCs) are observed across infections, yet their ontogeny and differentiation remain unclear. Using high-dimensional flow cytometry, single-cell transcriptomics, V(D)J sequencing, and functional assays in human malaria and healthy donors, we identified markers of cellular origin while tracking ABC differentiation. Early ABCs express CD11c and arise predominantly from memory B cells. Two intermedia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
84a953b1-4ef3-55c0-a2ab-534813ecb83c
DOI
10.1101/2025.09.15.676235
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
CD24 and CD27 resolve ontogeny and gradual differentiation of CD11c+ atypical memory B cells after malaria infectionDOI 10.1101/2025.09.15.676235
Atypical B cells are a normal component of immune responses to vaccination and infection in humansSemantic proximity
Maturation Trajectories and Transcriptional Landscape of Plasmablasts and Autoreactive B Cells in COVID-19Semantic proximity
Deep profiling of antigen-specific B cells from different pathogens identifies novel compartments in the IgG memory B cell and antibody-secreting cell lineagesSemantic proximity
Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19Semantic proximity
The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in MalariaSemantic proximity
IL-21 and IFN-alpha have both opposite and redundant role on human innate precursors and memory B-cell differentiationSemantic proximity
Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analysesSemantic proximity
Comprehensive analyses of B-cell compartments across the human body reveal novel subsets and a gut-resident memory phenotypeSemantic proximity
Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiationSemantic proximity
Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like PhenotypeSemantic proximity
Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell AnalysesSemantic proximity
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infectionSemantic proximity
Select a neighboring publication to make it the new centre.