Article
HLA Class II Protein Expression Regulation Is Strongly Linked to Cis-Acting SNPs.
HLA - 1 Apr 2026
Vince Nicolas, Ramsuran Veron, Viard Mathias, Martinson Jeremy, Wolinsky Steven, Hussain Shehnaz, Seaberg Eric C, Brown Todd T, Spence Niamh, Thio Chloe L, Goedert James J, Hoots W Keith, Kirk Gregory D, Carrington Mary
Abstract excerpt
Allele-specific variability in HLA class I gene expression levels has been associated with many diseases. Although expression variation at the allelic level has not been well-characterised for the HLA class II genes, differential expression of these genes, as marked by single nucleotide polymorphisms (SNPs), has been implicated in the outcome of several diseases. Here, we measured cell surface expression levels...
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