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Article

The influence of HLA genetic variation on plasma protein expression.

Nature communications - 31 Jul 2024

Krishna Chirag, Chiou Joshua, Sakaue Saori, Kang Joyce B, Christensen Stephen M, Lee Isac, Aksit Melis Atalar, Kim Hye In, von Schack David, Raychaudhuri Soumya, Ziemek Daniel, Hu Xinli

Abstract excerpt

Genetic variation in the human leukocyte antigen (HLA) loci is associated with risk of immune-mediated diseases, but the molecular effects of HLA polymorphism are unclear. Here we examined the effects of HLA genetic variation on the expression of 2940 plasma proteins across 45,330 Europeans in the UK Biobank, with replication analyses across multiple ancestry groups. We detected 504 proteins affected by HLA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39085222
DOI: 10.1038/s41467-024-50583-8
PMCID: PMC11291675

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