Article

Protofibril Binding Peptides Recognize and Inhibit Huntingtin Amyloid Formation <i>in vitro</i> and <i>in vivo</i>

2025-10-21

Abstract excerpt

In Huntingtons disease, polyglutamine expansion in huntingtin exon 1 (Httex1) results in stepwise misfolding, amyloid formation, and neuronal death. Here we used mRNA display directed evolution to generate peptide ligands targeting Httex1 protofibrils, an early, toxic misfolding intermediate. Two distinct peptide families bind protofibrils, one tryptophan rich and the other glutamine rich, resulting in two predomi...

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Literature Corpus work: 5b7c63e8-5d20-5d82-9300-bde6dd5c60fc
DOI: 10.1101/2025.10.21.680574

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