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Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin

17 Apr 2018

Abstract excerpt

The N-terminal fragments of mutant huntingtin (mHTT) misfold and assemble into oligomers, which ultimately bundle into insoluble fibrils. Conformations unique to various assemblies of mHTT remain unknown. Knowledge on the half-life of various multimeric structures of mHTT is also scarce. Using a panel of four new antibodies named PHP1-4, we have identified new conformations in monomers and assembled structures of...

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PMID: 29912367
DOI: 10.1093/hmg/ddy141

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