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AI-guided design and <i>ex vivo</i> validation of nanobodies targeting aggregation motifs of intrinsically disordered protein tau

2026-04-05

Abstract excerpt

Intrinsically disordered proteins (IDPs) represent major yet challenging therapeutic targets in neurodegenerative disease due to their conformational heterogeneity and aggregation-prone behavior. Tau protein is a prototypical IDP that forms pathological aggregates in Alzheimer’s disease and related tauopathies. Despite extensive clinical efforts, tau-directed monoclonal antibodies have demonstrated limited efficac...

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Literature Corpus work
7bf8dca4-bcdd-5395-83bf-bdff6a8b7198
DOI
10.64898/2026.04.01.715983
Open publication

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AI-guided design and <i>ex vivo</i> validation of nanobodies targeting aggregation motifs of intrinsically disordered protein tauDOI 10.64898/2026.04.01.715983
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