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Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets

22 Sept 2021

Abstract excerpt

Identifying genomic alterations of cancer proteins has guided the development of targeted therapies, but proteomic analyses are required to validate and reveal new treatment opportunities. Herein, we develop a new algorithm, OPPTI, to discover overexpressed kinase proteins across 10 cancer types using global mass spectrometry proteomics data of 1,071 cases. OPPTI outperforms existing methods by leveraging...

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PMID: 34552204
DOI: 10.1038/s42003-021-02636-7

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