Tumor-specific Kinase Motif Enrichment Analysis Identifies Personalized Therapeutic Cancer Targets

Abstract excerpt

<h4>ABSTRACT</h4> Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are an uncommon and poorly understood malignancy with low mutational burden, lacking well-defined oncogenic drivers. GEP-NET mortality frequently results from extensive hepatic metastases. Accordingly, we interrogated phosphoproteomic data from GEP-NET liver metastases and patient-matched uninvolved liver to identify tumor-specific signalin...

Topics

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• Cancer Genomics and Diagnostics
• Cancer Mechanisms and Therapy
• Cancer-related Molecular Pathways
• Gastric Cancer Management and Outcomes
• Mutation
• Neoplasms
• Pancreatic and Hepatic Oncology Research
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

8538b4bb-56e4-56a4-a7a7-34d92dbf20f9

DOI

10.64898/2026.07.31.742097