Article

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs

2019-11-20

Abstract excerpt

<h4>ABSTRACT:</h4> Kinase-dependent signaling networks are frequently dysregulated in cancer, driving disease progression. While kinase inhibition has become an important therapeutic approach many cancers resist drug treatment. Therefore, we need both reliable biomarkers that predict drug responses and new targets to overcome drug resistance. Determining the kinase(s) that control cancer progression in individual...

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Literature Corpus work: 11256907-c211-5e96-9666-bc96b49d1a43
DOI: 10.1101/849281

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