Article

Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

2020-08-21

Abstract excerpt

Cryptococcal disease is estimated to affect nearly a quarter of a million people annually. Environmental isolates of Cryptococcus deneoformans , which make up 15 to 30% of clinical infections in temperate climates such as Europe, vary in their pathogenicity, ranging from benign to hyper-virulent. Key traits that contribute to virulence, such as the production of the pigment melanin, an extracellular polysaccharid...

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Literature Corpus work: 5b7a22dd-8755-5b93-868c-9d07e8143207
DOI: 10.1101/2020.08.21.259861

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