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Unraveling Melanin Biosynthesis and Signaling Networks in Cryptococcus neoformans

30 Sept 2019

Abstract excerpt

Melanins are dark green, brown, or black pigments that serve as antioxidant, reactive oxygen species (ROS) scavengers that protect fungal pathogens from radiation and host immune responses. Cryptococcus neoformans , the major etiological agent of fungal meningoencephalitis, also utilizes melanin as a key virulence factor. In this basidiomycete pathogen, melanin production is regulated by the cAMP and...

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PMID: 31575776
DOI: 10.1128/mbio.02267-19

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