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Article

Genetic Factors and Genotype-Environment Interactions Contribute to Variation in Melanin Production in the Fungal Pathogen Cryptococcus neoformans.

Scientific reports - 29 Jun 2018

Samarasinghe Himeshi, Aceituno-Caicedo David, Cogliati Massimo, Kwon-Chung Kyung J, Rickerts Volker, Velegraki Aristea, Ackaglar Sevim, Xu Jianping

Abstract excerpt

Cryptococcosis is a common opportunistic fungal infection that often disseminates into the central nervous system, leading to meningitis. Production of melanin pigments during infections is one of the most important virulence factors of its causal agent, the human pathogenic yeast Cryptococcus neoformans species complex. However, almost nothing is known about the patterns of variation in melanin production among...

Topics

Cryptococcosis
Cryptococcus neoformans
Gene-Environment Interaction
Genotype
Humans
Melanins
Phenotype
Virulence
Virulence Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29959391
DOI: 10.1038/s41598-018-27813-3
PMCID: PMC6026209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29959391-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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